Semeglutide Intermediate Fmoc-AEEA CAS 166108-71-0

Product Description

Semeglutide Intermediate Fmoc-AEEA CAS 166108-71-0

Name: Fmoc-Aeea

CAS NO: 166108-71-0

M.W:385.41

Appearance: White Powder

Purity: 98+

Synonyms: Fmoc-8-amino-3,6-dioxaoctanoic acid

Application

Fmoc-AEEA ([2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid) plays a significant role in various fields.

Firstly, it serves as a crucial intermediate in the synthesis of fourth-generation anti-HIV drugs, such as Elabot. Through specific chemical coupling processes, Fmoc-AEEA is able to attach to gp41 peptide fragments and other modified analogues, enhancing their stability within the body and reducing their susceptibility to degradation by peptidases or proteases. This makes Fmoc-AEEA an important component in the development of more effective antiviral drugs against pathogens like the Human Immunodeficiency Virus (HIV).

Secondly, in the field of medicinal chemistry, AEEA is introduced as a hydrophilic spacer into certain drug structures, including semaglutide (also known as Somaglutide). It enhances the solubility of peptides in aqueous solutions, significantly improving the bioavailability of drugs. By promoting tight binding of peptides to albumin, AEEA effectively shields certain enzymatic cleavage sites, preventing enzymatic degradation and thereby extending the half-life of the peptides. This allows the drugs to circulate continuously in the bloodstream. This strategy is crucial in peptide drug design as it can enhance therapeutic effects and potentially reduce the frequency of dosing.

In summary, Fmoc-AEEA plays a pivotal role in both anti-HIV drug synthesis and peptide drug design. It enhances the stability and bioavailability of drugs, leading to improved therapeutic outcomes. However, further research and experiments may be necessary to fully understand its specific mechanism of action in particular drugs such as semaglutide.

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