Glatiramer Acetate Intermediate L-Glu(Obzl)-NCA CAS 3190-71-4 N-Carboxyanhydride

Product Description

Glatiramer acetate intermediate L-Glu(Obzl)-NCA CAS 3190-71-4 N-Carboxyanhydride(NCA)

Name: L-Glu(Obzl)-NCA

CAS NO: 3190-71-4

M.W: 263.25

Appearance: White Powder

Purity: 98+   

Synonyms: 5-Benzyl L-glutamate N-carboxyanhydride, Glutamic acid-5-benzyl ester-NCA

Application

L-Glu(Obzl)-NCA, or L-glutamic acid γ-benzyl ester N-carboxyanhydride, plays a pivotal role in the synthesis of glatiramer acetate. Glatiramer acetate, a polypeptide drug composed of multiple amino acid residues, is primarily used to treat multiple sclerosis. Its synthesis requires precise control of each reaction step to ensure the biological activity and therapeutic efficacy of the final product.

During the synthesis process, L-Glu(Obzl)-NCA, as an important amino acid derivative, undergoes condensation reactions with other amino acids or peptide fragments to gradually construct the molecular skeleton of glatiramer acetate. Due to its specific chemical properties and reactivity, L-Glu(Obzl)-NCA can effectively bind with other components to form stable chemical bonds.

Furthermore, the benzyl ester group in L-Glu(Obzl)-NCA plays a crucial role in the synthesis. This group not only helps protect sensitive functional groups in amino acids from unwanted side reactions during the process but can also be removed through subsequent deprotection steps to yield glatiramer acetate molecules with desired functional groups.

It's worth noting that the synthesis of glatiramer acetate is a complex and delicate process involving multiple steps and raw materials. In addition to L-Glu(Obzl)-NCA, other crucial amino acid derivatives and reagents are also involved. Therefore, it is necessary to strictly control the reaction conditions, optimize the reaction steps, and ensure the efficient progress and purity of each step during the synthesis process.

By deeply studying the mechanism of L-Glu(Obzl)-NCA's role in the synthesis of glatiramer acetate, we can better understand the drug's synthesis process, providing strong support for optimizing the synthesis process, improving yield and quality. At the same time, this also provides useful references and inspirations for the development of novel polypeptide drugs or the improvement of existing drugs.

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Transportation

Small package(1g, 25g, 1Kg, 25Kg) can be shipped by Express. (DHL, FedEx, EMS, etc.)
Large package(100kg and more than100Kg) can be transported by Air or Sea.

All transportation is in accordance with the customer's needs.

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