Glatiramer Acetate Intermediate L-Lys(Tfa)-NCA CAS 42267-27-6

Product Description

Glatiramer acetate intermediate L-Lys(Tfa)-NCA CAS 42267-27-6

Name: L-Lys(tfa)-NCA

CAS NO: 42267-27-6

M.W:268.19

Appearance: White Powder

Purity: 98+   

Synonyms: Lysine(TFA)-NCA, N-Trifluoroacetyl-L-lysine N-carboxyanhydride

Application

L-Lys(tfa)-NCA, or L-lysine trifluoroacetyl N-carboxyanhydride, plays a pivotal role in the synthesis of glatiramer acetate. Glatiramer acetate, an artificial polypeptide drug used to treat multiple sclerosis, requires precise control of each synthetic step to ensure the activity and stability of the final product.

Firstly, L-Lys(tfa)-NCA, as a specific amino acid derivative, possesses unique chemical properties and reactivity. During the synthesis process, it efficiently and specifically undergoes condensation reactions with other amino acids or peptide fragments, gradually building up the molecular framework of glatiramer acetate. This precise synthesis method ensures the integrity and correctness of the molecular structure of glatiramer acetate.

Secondly, the introduction of L-Lys(tfa)-NCA also contributes to optimizing the biological properties of glatiramer acetate. Lysine, an alkaline amino acid, has functions in regulating the immune system and cellular metabolism. In glatiramer acetate, the presence of lysine may enhance the interaction between the drug and the immune system, thereby improving its therapeutic effect. Additionally, the introduction of the trifluoroacetyl group may further modulate the solubility and stability of the drug, improving its absorption and distribution within the body.

Furthermore, L-Lys(tfa)-NCA may positively impact the pharmacological effects of glatiramer acetate. Multiple sclerosis is a chronic disease caused by the immune system attacking the nervous system. Glatiramer acetate works by mimicking myelin proteins to reduce immune responses and inflammation caused by abnormal nervous system activity. The specific structure of L-Lys(tfa)-NCA may enhance the interaction between glatiramer acetate and the immune system, further improving its anti-inflammatory and immune-modulatory effects.

It's worth noting that the synthesis of glatiramer acetate is a complex and delicate process involving multiple steps and raw materials. In addition to L-Lys(tfa)-NCA, other crucial amino acid derivatives and reagents are also involved. Therefore, it is necessary to strictly control the reaction conditions, optimize the reaction steps, and ensure the efficient progress and purity of each step during the synthesis process.

Package

Transportation

Small package(1g, 25g, 1Kg, 25Kg) can be shipped by Express. (DHL, FedEx, EMS, etc.)
Large package(100kg and more than100Kg) can be transported by Air or Sea.

All transportation is in accordance with the customer's needs.

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