Polyamino acid PAA Orn(Z)-NCA CAS NO. 13296-21-4

Product Description

Polyamino acid PAA Orn(Z)-NCA CAS NO. 13296-21-4

Name: Orn(Z)-NCA

CAS NO: 13296-21-4

M.W:292.29

Appearance: White Powder

Purity: 98+   

Synonyms: Ornithine(Z)-NCA, Carbamic acid, N-[3-[(4S)-2,5-dioxo-4-oxazolidinyl]propyl]-, phenylmethyl ester

Application

Polyamino acids are polymers formed by connecting amino acid monomers through specific chemical bonds. These polymers have extensive applications in areas such as biomaterials, drug delivery, and tissue engineering due to their biocompatibility and degradability, making them attractive alternatives to traditional synthetic materials.

Orn(Z)-NCA, or Z-ornithine-N-carboxyanhydride, is a specific NCA (N-carboxyanhydride) monomer. In the synthesis of polyamino acids, Orn(Z)-NCA can participate in the formation of polymer chains through ring-opening polymerization reactions along with other amino acid monomers. By controlling the amount of Orn(Z)-NCA added and the polymerization conditions, precise modulation of the molecular structure, chain length, molecular weight distribution, and functionality of polyamino acids can be achieved.

Specifically, the introduction of Orn(Z)-NCA can alter the charge properties, hydrophilicity/hydrophobicity, and biological activity of polyamino acids, thereby affecting their interactions with biological tissues, drug loading and release performance, as well as their degradation rates within the biological body. These property changes are crucial for the performance of polyamino acids in specific application scenarios.

Furthermore, Orn(Z)-NCA, as a monomer with specific functional groups, can also provide additional functionalization sites for polyamino acids, enabling further chemical modifications or conjugation with other biological molecules (such as proteins, DNA, etc.). This functionalization capability holds potential for the construction of multifunctional biomaterials or drug delivery systems using polyamino acids.

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