Semaglutide intermediate Fmoc-Arg(pbf)-OH CAS 154445-77-9 Bulk Production

Product Description

Semaglutide intermediate Fmoc-Arg(pbf)-OH CAS 154445-77-9 Bulk Production

Name: Fmoc-Arg(pbf)-OH

CAS NO: 154445-77-9

M.W: 648.77

Appearance: White Powder

Purity: 98+  

Synonyms: Fmoc-pbf-L-Arginine

Application

To synthesize semaglutide using Fmoc-Arg(pbf) as one of the components, the general steps involve:

Initially, the Fmoc-protected dipeptide fragment Fmoc-Arg(Pbf)-Gly-OH is coupled to a solid-phase resin carrier, resulting in Fmoc-Arg(Pbf)-Gly-resin. The solid-phase carrier can be polystyrene-based resins such as Wang resin, CTC resin, or PHB resin.

Subsequently, N-terminal Fmoc-protected and side chain-protected amino acids as well as dipeptide fragments are sequentially coupled in accordance with the peptide sequence of semaglutide. This step involves chemically linking amino acids in a specific order to form the peptide chain of semaglutide.

Once the peptide chain synthesis is complete, the peptide resin is cleaved to obtain the peptide backbone. This step removes the resin carrier and transfers the peptide from the solid phase to the liquid phase.

Next, the side chain is attached to the ε-NH of the lysine residue at position 20, and the protective groups are removed. This step completes the side chain modification and deprotection of semaglutide, enabling its biological activity.

Finally, semaglutide is purified to obtain the final product. Purification steps may include filtration, crystallization, chromatography separation, and other methods to remove impurities and improve the purity and quality of the product.

Package

Transportation

Small package(1g, 25g, 1Kg, 25Kg) can be shipped by Express. (DHL, FedEx, EMS, etc.)
Large package(100kg and more than100Kg) can be transported by Air or Sea.

All transportation is in accordance with the customer's needs.

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