Semaglutide intermediate Fmoc-Thr(tBu)-OH CAS 71989-35-0 HPLC 99.5+

Product Description

Semaglutide intermediate Fmoc-Thr(tBu)-OH CAS 71989-35-0 HPLC 99.5+

Name: Fmoc-Thr(tBu)-OH

CAS NO: 771989-35-0

M.W: 397.46

Appearance: White Powder

Purity: 98+

Synonyms: Fmoc-O-tert-Butyl-L-Threonine

Application

The role of Fmoc-Thr(tBu)-OH in Semaglutide

Fmoc-Thr(tBu)-OH serves as a component of Semaglutide, specifically representing one of the amino acids in its amino acid sequence, threonine (Thr), with its hydroxyl group (OH) protected by a tert-butyl group (tBu).

Semaglutide is a medication similar to glucagon-like peptide-1 (GLP-1) used primarily for the treatment of type 2 diabetes. It regulates the secretion of insulin and glucagon to lower blood sugar levels. Specifically, when blood sugar levels are high, Semaglutide promotes insulin secretion to lower blood sugar, and in cases of potential hypoglycemic risk, it can stimulate glucagon secretion to avoid hypoglycemia.

During the synthesis of Semaglutide, the use of protected amino acids like Fmoc-Thr(tBu)-OH ensures stability and selectivity during the peptide chain assembly. Fmoc (9-fluorenylmethoxycarbonyl) is a commonly used amino-protecting group in solid-phase peptide synthesis (SPPS). The tert-butyl group (tBu) is used to protect the hydroxyl group of threonine, preventing unwanted reactions during synthesis.

In summary, Fmoc-Thr(tBu)-OH plays a crucial role in the synthesis of Semaglutide, ensuring its correct synthesis and biological activity.

Package

Transportation

Small package(1g, 25g, 1Kg, 25Kg) can be shipped by Express. (DHL, FedEx, EMS, etc.)
Large package(100kg and more than100Kg) can be transported by Air or Sea.

All transportation is in accordance with the customer's needs.

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