Peptide Intermediate Fmoc-His(Mtt)-OH CAS 133367-34-7 HPLC 99+

Product Description

Peptide Intermediate Fmoc-His(Mtt)-OH CAS 133367-34-7 HPLC 99+

Name: Fmoc-L-His(Mtt)-OH

CAS NO: 133367-34-7

M.W: 633.73

Appearance: White Powder

HPLC: 99+  

Synonyms: N-α-Fmoc-N-im-methyltrityl-L-histidine

Application

Protection and Stability: The Fmoc (9-fluorenylmethyloxycarbonyl) group protects the α-amino group of the amino acid, preventing it from reacting prematurely with the carboxyl groups of other amino acids during the synthesis process. The Mtt (most likely referring to a side chain protecting group like methoxytrityl) protects the imidazole side chain of histidine, ensuring its stability and preventing unwanted side reactions.

Controllability: By using amino acid derivatives with protecting groups, researchers can precisely control the sequence and structure of the resulting polypeptide. In solid-phase peptide synthesis, these derivatives are added stepwise to the growing peptide chain, with each addition followed by the removal of the protecting groups to expose the reactive sites for the next addition.

Efficiency: Solid-phase peptide synthesis methods utilize solid supports like resins to anchor one end of the peptide chain. This allows for an efficient, automated process where amino acid derivatives are sequentially added and protecting groups removed to elongate the peptide chain.

Mimicking Natural Peptides: In cases where Fmoc-His(Mtt) is used to mimic a histidine residue in a natural peptide, it can help researchers study the function or interactions of that particular residue within the context of the larger peptide structure.

Metal Ion Binding: Since histidine possesses a unique imidazole side chain that can coordinate with metal ions, Fmoc-His(Mtt) may be a crucial component when synthesizing peptides with metal ion-binding sites. The protected form ensures that the imidazole group remains available for metal ion coordination after the peptide is synthesized.

Package

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