Peptide Intermediate Fmoc-Lys(mtt)-OH CAS 167393-62-6 HPLC 99+

Product Description

Peptide Intermediate Fmoc-Lys(mtt)-OH CAS 167393-62-6 HPLC 99+

Name: Fmoc-Lys(mtt)-OH

CAS NO: 167393-62-6

M.W: 624.77

Appearance: White Powder

HPLC: 99+  

Synonyms: Fmoc-Lys(mtt)

Application

Protection of Reactive Groups: During peptide synthesis, some amino acid side chains may contain reactive groups such as amino, carboxyl, or hydroxyl groups. These groups can participate in undesirable side reactions, affecting the synthesis efficiency and purity of the peptide. Fmoc-Lys(mtt)-OH functions as a protecting group that selectively binds to these reactive groups, stabilizing them during the synthesis process and preventing unwanted reactions.

Orthogonal Protection Strategy: In addition to protecting the side chain groups, the α-amino group also needs to be protected during peptide synthesis. The Fmoc group (fluorenylmethyloxycarbonyl) in Fmoc-Lys(mtt)-OH modifies the N of the α-amino group, serving as a protecting group. This protecting group forms an orthogonal protection strategy with the side chain protecting group (such as methyltrityl, abbreviated as Mtt), meaning that they do not interfere with each other during the reaction conditions and can undergo deprotection and condensation reactions separately.

Ease of Deprotection: A significant advantage of the Fmoc protecting group is its ease of removal under acidic conditions (such as trifluoroacetic acid, TFA). After completing the peptide synthesis, the Fmoc protecting group can be removed through simple acid treatment, releasing the target peptide. Furthermore, the Fmoc protecting group is extremely stable to acids, ensuring that the peptide structure remains intact during deprotection.

Physical Properties and Storage Conditions: The molecular formula of Fmoc-Lys(mtt)-OH is C41H40N2O5, with a molecular weight of 640.767. Its density is approximately 1.2±0.1 g/cm3, and its boiling point is estimated to be around 814.1±65.0 °C at 760 mmHg. These physical properties provide reference for handling and storage during synthesis. To ensure stability and purity, it should be stored under sealed conditions at -20°C.

Package

Transportation

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Large package(100kg and more than100Kg) can be transported by Air or Sea.

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