Liraglutide Intermediate Boc-His(Trt)-Ala-OH HPLC 99+

Product Description

Liraglutide Intermediate Boc-His(Trt)-Ala-OH HPLC 99+

Name: Boc-His(Trt)-Ala-OH

CAS NO: N/A

M.W: 568.67

Appearance: White Powder

Purity: 99+   

Synonyms: Boc-His(Trt)-Ala-OH

Application

As a Synthetic Fragment:

In the synthesis of liraglutide, Boc-His(Trt)-Ala-OH serves as a synthetic fragment. Using solid-phase or liquid-phase peptide synthesis techniques, this fragment is connected step-by-step with other amino acid fragments to form the complete liraglutide molecule.
This process involves multiple steps, including amino acid activation, coupling, and deprotection, each requiring precise control to ensure the purity and activity of the final product.

Indirectly Influencing Drug Properties:

While Boc-His(Trt)-Ala-OH itself does not directly extend the half-life of liraglutide, its presence as part of the liraglutide molecular structure contributes to overall stability, which may indirectly affect bioavailability and half-life.
The specific design of liraglutide, such as the lipophilic side chain of lysine (N-palmitoyl-γ-glutamate), is the primary factor responsible for its extended half-life.

Enhancing Synthetic Efficiency:

Using Boc-His(Trt)-Ala-OH as a synthetic fragment improves the efficiency and yield of the synthesis process. This pre-synthesized fragment reduces complexity and the potential for errors in subsequent steps.
By optimizing synthesis conditions and reaction parameters (e.g., solvent, temperature, reaction time), further enhancements in synthesis efficiency and product purity can be achieved.

Package

Transportation

Small package(1g, 25g, 1Kg, 25Kg) can be shipped by Express. (DHL, FedEx, EMS, etc.)
Large package(100kg and more than100Kg) can be transported by Air or Sea.

All transportation is in accordance with the customer's needs.

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