Liraglutide Intermediate CAS. 1428125-85-2 Boc-His(Trt)-Gly-OH HPLC 99+

Product Description

Liraglutide Intermediate CAS. 1428125-85-2 Boc-His(Trt)-Gly-OH HPLC 99+

Name: Boc-His(Trt)-Gly-OH

CAS NO: 1428125-85-2

M.W: 554.64

Appearance: White Powder

Purity: 99+   

Synonyms: Boc-His(Trt)-Gly-OH

Application

As a Starting or Key Fragment

Starting Point: In the intricate process of synthesizing liraglutide, Boc-His(Trt)-Gly-OH (or its longer variants) often serves as a starting or key fragment in the synthetic pathway. This fragment is prepared through solid-phase synthesis or other chemical methods and serves as the foundation for subsequent reactions.

Application in the Synthetic Strategy

Fragment Condensation Approach: When synthesizing liraglutide, the fragment condensation approach is often employed. This method involves dividing the complex peptide chain into smaller, more manageable fragments that are easier to synthesize. These fragments are then connected through specific chemical reactions to form the complete liraglutide sequence. Boc-His(Trt)-Gly-OH (or its variant) is one of these fragments. Threonine Ligation: In particular, threonine ligation is a common fragment ligation method that relies on the imine capture reaction between the side-chain hydroxyl group of serine/threonine and an aldehyde. In this method, the C-terminus of Boc-His(Trt)-Gly-OH (or its variant) may be converted into a salicylaldehyde ester for ligation with the N-terminal threonine of another fragment.

Role in Specific Synthesis Steps

Protecting Groups: The protecting groups such as Boc and Trt play a crucial role in protecting the side-chain functionalities of amino acids during synthesis, preventing unwanted reactions. These protecting groups are removed in subsequent steps to expose the reactive functionalities for further coupling reactions. Coupling Reactions: During the synthesis of liraglutide, Boc-His(Trt)-Gly-OH (or its variant) is coupled with other peptide segments or amino acids through coupling reactions. These coupling reactions typically occur in suitable solvents and in the presence of catalysts to ensure high efficiency and specificity.

Package

Transportation

Small package(1g, 25g, 1Kg, 25Kg) can be shipped by Express. (DHL, FedEx, EMS, etc.)
Large package(100kg and more than100Kg) can be transported by Air or Sea.

All transportation is in accordance with the customer's needs.

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