Tilpotide Intermediate Fmoc-Ile-OH CAS NO. 71989-23-6 HPLC 99+

Product Description

Tilpotide intermediate Fmoc-Ile-OH CAS NO. 71989-23-6 HPLC 99+

Name: Fmoc-L-Ile-OH

CAS NO: 71989-23-6

M.W: 353.41

Appearance: White Powder

HPLC: 99+

Synonyms: N-FMOC-L-ISOLEUCINE; N-FMOC-ILE-OH; Fmoc-(2S,3S)-2-amino-3-methylpentanoic acid

Application

Role of the Protection Group:Fmoc (9-fluorenylmethoxycarbonyl), serving as an alkaline-sensitive protecting group, is commonly utilized in polypeptide synthesis to safeguard the N-terminus of amino acids. As an Fmoc-protected derivative of isoleucine, Fmoc-isoleucine effectively prevents undesirable reactions at the amino group during the synthesis process, ensuring precision and efficiency in the synthetic steps.

Enhancing Synthesis Efficiency:The selection of amino acid protecting groups significantly impacts the efficiency and yield of polypeptide synthesis. Fmoc-isoleucine, with its stability and reactivity, enables the efficient introduction of isoleucine residues through amidation reactions during the elongation of the polypeptide chain, while simultaneously protecting its N-terminus from interference. This characteristic accelerates the synthesis rate and optimizes the purity of the product.

Potential for Structural Modification:The reactive carboxyl and amide groups of Fmoc-isoleucine allow it to undergo condensation reactions with alcohols or amines, leading to the synthesis of desired ester or amide derivatives. This capability positions Fmoc-isoleucine as a crucial player in the structural modification of polypeptides. In the synthesis or subsequent applications of Tilpotide, if specific structural modifications are required to enhance its stability, biological activity, or pharmacokinetic properties, Fmoc-isoleucine may be introduced as a valuable intermediate or starting material.

Package

Transportation

Small package(1g, 25g, 1Kg, 25Kg) can be shipped by Express. (DHL, FedEx, EMS, etc.)
Large package(100kg and more than100Kg) can be transported by Air or Sea.

All transportation is in accordance with the customer's needs.

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