Fmoc-AEEA-OPFP CAS NO. 1263044-39-8 White Powder Purity 99+

Product Description

Fmoc-AEEA-OPFP CAS NO. 1263044-39-8 White Powder Purity 99+

Name: Fmoc-AEEA-OPFP

CAS NO: 1263044-39-8

M.W: 551.46

Appearance: White Powder

Purity: 99+  

Synonyms: Fmoc-Ado-OPfp

Application

The AEEA (aminoethyl ethanedioic acid) moiety, on the other hand, may be utilized to introduce specific side-chain structures, which often impart specific biological activities or improve the pharmacokinetic properties of polypeptide drugs. For instance, in some anti-diabetic polypeptide drugs, such as GLP-1 receptor agonists, the introduction of an AEEA side chain can significantly enhance the hydrophilicity of the drug molecule, increasing its binding affinity to albumin, thereby prolonging its half-life, reducing the dosing frequency, and improving patient compliance.

OPFP (pentafluorophenol ester), as a carboxyl protecting group, is commonly used to protect the carboxyl group of amino acids or peptide segments during polypeptide synthesis, preventing undesired esterification or amidation reactions. Under appropriate conditions, the OPFP protecting group can be removed, exposing the free carboxyl group for subsequent coupling or modification reactions.

Therefore, Fmoc-AEEA-OPFP, as a chemical intermediate that combines the Fmoc protecting group, AEEA side chain, and OPFP protecting group, plays a significant role in the synthesis and modification of polypeptide drugs. It can be introduced into the polypeptide chain via various methods, such as solid-phase synthesis or liquid-phase synthesis, to produce polypeptide drugs with specific biological activities and pharmacokinetic properties.

Package

Transportation

Small package(1g, 25g, 1Kg, 25Kg) can be shipped by Express. (DHL, FedEx, EMS, etc.)
Large package(100kg and more than100Kg) can be transported by Air or Sea.

All transportation is in accordance with the customer's needs.

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