Peptide Raw Material Fmoc-α-Me-L-Leu-OH CAS No 312624-65-0 HPLC 99+

Product Description

Peptide Raw Material Fmoc-α-Me-L-Leu-OH CAS No 312624-65-0 HPLC 99+

Name: Fmoc-α-Me-L-Leu-OH

CAS NO: 312624-65-0

M.W: 367.44

Appearance: White Powder

HPLC: 99+  

Synonyms: Fmoc-α-Methyl-L-Leucine

Application

1. Used in the synthesis of conformationally constrained peptides

The α-methyl group restricts the backbone flexibility, helping to stabilize specific secondary structures such as α-helices or β-turns.

Commonly used in the design of peptidomimetics and folded peptides.

2. Improves resistance to enzymatic degradation

The α-methylation makes the peptide bond less recognizable to proteases, enhancing the metabolic stability and in vivo half-life of the peptide.

Useful in therapeutic peptide development.

3. Structure-activity relationship (SAR) studies

Introducing α-Me-L-Leu at key positions helps researchers explore the relationship between structure and biological activity, especially in protein–protein interaction (PPI) inhibitors.

4. Peptide drug development

Frequently used in the development of peptides targeting cancer, viral infections, or inflammation, where improved stability and bioavailability are needed.

5. Hydrophobic modification

The methyl and leucine side chains enhance hydrophobicity, potentially improving cell membrane permeability or target binding.

Package

Transportation

Small package(1g, 25g, 1Kg, 25Kg) can be shipped by Express. (DHL, FedEx, EMS, etc.)
Large package(100kg and more than100Kg) can be transported by Air or Sea.

All transportation is in accordance with the customer's needs.

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