Raw Materials For Peptide Fmoc-α-Me-Phe-OH CAS No 135944-05-7 HPLC 99+

Product Description

Raw Materials For Peptide Fmoc-α-Me-Phe-OH CAS No 135944-05-7 HPLC 99+

Name: Fmoc-α-Me-Phe-OH

CAS NO: 135944-05-7

M.W: 401.45

Appearance: White Powder

HPLC: 99+  

Synonyms: 
Fmoc-alpha-methyl-L-Phe

Application

1. Backbone Conformational Restriction

The α-methyl group introduces steric hindrance that locks the peptide backbone in specific conformations.

Often used to stabilize α-helical or β-turn structures, important in bioactive peptides.

2. Increased Protease Resistance

The α-methyl group makes the amide bond less recognizable to proteolytic enzymes, increasing peptide stability in biological environments.

Useful in the design of longer-lasting peptide therapeutics.

3. Peptidomimetic Design

Frequently used in PPI inhibitors and receptor-binding peptides, where structure rigidity and hydrophobic/aromatic interactions (from phenyl side chain) are key.

Helps mimic bioactive conformations of natural peptides.

4. Pharmacokinetic Improvements

α-Me-Phe improves membrane permeability, bioavailability, and metabolic stability, contributing to better drug-like properties.

Package

Transportation

Small package(1g, 25g, 1Kg, 25Kg) can be shipped by Express. (DHL, FedEx, EMS, etc.)
Large package(100kg and more than100Kg) can be transported by Air or Sea.

All transportation is in accordance with the customer's needs.

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