ADC Starting Material Gly-Gly-Phe CAS 6234-26-0

Product Description

ADC Starting Material Gly-Gly-Phe CAS 6234-26-0

Name: Gly-Gly-Phe

CAS NO: 6234-26-0

M.W: C13H17N3O4

Appearance: White Powder

Purity: 98+

Synonyms: GLYCYL-GLYCYL-L-PHENYLALANINE;

Application

1. Cathepsin B-Cleavable Linker Component

The Gly-Gly-Phe sequence is recognized and cleaved by lysosomal proteases, particularly cathepsin B, which is overexpressed in many tumor cells.

Upon internalization of the ADC into tumor cells, the peptide is enzymatically cleaved, triggering drug release inside the cell.

2. Final Structure in Linker-Payload Design

Unlike Fmoc-protected versions (used in synthesis), Gly-Gly-Phe-OH is the active, deprotected form used in the final assembly of the ADC linker-payload unit.

It is typically conjugated to:

PABC (para-aminobenzyloxycarbonyl) as a self-immolative spacer,

then to the cytotoxic payload (e.g., MMAE, DM1, etc.).

3. Common Linker Structure Example in ADCs

Antibody — (Val-Cit)-(Phe/Phe-Gly-Gly) — PABC — Drug

In some designs, Val-Cit or Gly-Gly-Phe or even Gly-Phe-Leu-Gly motifs are used for enhanced selectivity or enzyme targeting.

Gly-Gly-Phe contributes to:

Cleavability by tumor enzymes

Stability in plasma

Efficient payload release

Package

Transportation

Small package(1g, 25g, 1Kg, 25Kg) can be shipped by Express. (DHL, FedEx, EMS, etc.)
Large package(100kg and more than100Kg) can be transported by Air or Sea.

All transportation is in accordance with the customer's needs.

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