α-Me Series Fmoc-α-Me-Leu-OH CAS 312624-65-0 HPLC 99+

Product Description

α-Me Series Fmoc-α-Me-Leu-OH CAS 312624-65-0 HPLC 99+

Name: Fmoc-α-Me-Leu-OH

CAS NO: 312624-65-0

M.W: 367.44

Appearance: White Powder

HPLC: 99+  

Synonyms: Fmoc-α-methyl-L-Leucine

Application

1. Process Simplification

Fmoc-α-Me-Leu-OH only carries one protecting group (Fmoc) on the amino group, with a free carboxyl group and no need for side chain protection (since Leu has no reactive side chain).

Dual-protected amino acids often require additional deprotection steps (e.g., Boc/Fmoc switching, side chain removal), making the synthesis more complex and lowering overall yield.

2. Compatibility with Standard SPPS

Fmoc-amino acids are the mainstream choice for solid-phase peptide synthesis (SPPS) since Fmoc can be removed under mild basic conditions, without affecting peptide bonds.

Dual-protected amino acids may introduce incompatibility in automated synthesis, leading to side reactions or material loss.

3. Advantage of α-Methylation

The α-methyl substitution in α-Me-Leu increases conformational rigidity of the peptide bond and enhances resistance to enzymatic degradation (improves stability and biological activity).

A single Fmoc protection is sufficient for peptide assembly, and no additional protection is needed to stabilize the structure.

4. Cost & Practicality

Single-protected Fmoc-α-Me-Leu-OH is usually less expensive and has a shorter synthetic route compared to dual-protected versions.

Dual protection is mainly useful in special peptide designs (e.g., cyclic peptides, selective modifications), but it is unnecessary for routine linear peptide synthesis.

Package

Transportation

Small package(1g, 25g, 1Kg, 25Kg) can be shipped by Express. (DHL, FedEx, EMS, etc.)
Large package(100kg and more than100Kg) can be transported by Air or Sea.

All transportation is in accordance with the customer's needs.

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