α-Me Series Protected Fmoc-α-Me-Tyr(tBu)-OH CAS 1309873-74-2 HPLC 99+

Product Description

α-Me Series Protected Fmoc-α-Me-Tyr(tBu)-OH CAS 1309873-74-2 HPLC 99+

Name: Fmoc-α-Me-Tyr(tBu)-OH

CAS NO: 1309873-74-2

M.W: 473.56

Appearance: White Powder

HPLC: 99+  

Synonyms: Fmoc-al-methyl-L-tyrosine(tBu)-O

Application

Efficient SPPS compatibility

Fmoc strategy is the most common in automated solid-phase peptide synthesis.

The tBu protecting group on Tyr is stable under basic Fmoc-removal conditions but can be cleanly removed under strong acid (TFA) at the end.

Prevention of side reactions

Tyr’s hydroxyl group can participate in undesired acylation or oxidation; tBu protection prevents this.

Enhanced peptide stability

The α-methyl substitution increases conformational rigidity, reduces enzymatic cleavage, and may alter the peptide’s secondary structure for improved biological activity.

Selective deprotection

You can remove Fmoc during elongation (base-labile).

Keep tBu intact until final global deprotection (acid-labile).

This orthogonality is ideal for SPPS.

Package

Transportation

Small package(1g, 25g, 1Kg, 25Kg) can be shipped by Express. (DHL, FedEx, EMS, etc.)
Large package(100kg and more than100Kg) can be transported by Air or Sea.

All transportation is in accordance with the customer's needs.

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