Alpha-Me Protected Fmoc-α-Me-Tyr-OH CAS 246539-83-3 High Purity

Product Description

Alpha-Me Protected Fmoc-α-Me-Tyr-OH CAS 246539-83-3 High Purity

Name: Fmoc-α-Me-Tyr-OH

CAS NO: 246539-83-3

M.W: 417.45

Appearance: White Powder

HPLC: 99+  

Synonyms: (S)-Fmoc-α-Me-Tyr-OH

Application

1. Enhancing Peptide Stability

α-Methylation restricts backbone rotation, making the peptide chain more rigid.

Increases resistance to proteolytic degradation, extending the half-life of therapeutic peptides.

Commonly applied in the design of drug-like, protease-stable peptides.

2. Modulating Peptide Conformation

α-Methylation can promote or stabilize certain secondary structures (e.g., α-helix, β-turns).

Useful in structural biology to probe peptide–protein interaction conformational preferences.

3. Improving Receptor Selectivity & Activity

Incorporation of α-methyltyrosine can:

Enhance receptor selectivity of peptide ligands;

Modulate binding affinity and functional activity;

Widely explored in GPCR ligands, peptide hormones, and mimetics.

4. Chemical Biology & Functionalization

The free phenolic OH of Tyr allows further on-resin modifications (e.g., phosphorylation, fluorophore labeling, bioconjugation).

Applied in studying signal transduction pathways involving tyrosine phosphorylation.

5. Specialty Peptide Design

Used in the synthesis of cyclic peptides, β-peptides, and backbone-modified analogues to improve metabolic stability and PK profiles.

Valuable in ADC (antibody–drug conjugates) or peptide–drug conjugates, where metabolic robustness is required.

Package

Transportation

Small package(1g, 25g, 1Kg, 25Kg) can be shipped by Express. (DHL, FedEx, EMS, etc.)
Large package(100kg and more than100Kg) can be transported by Air or Sea.

All transportation is in accordance with the customer's needs.

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