Fmoc-α-Me-Pro-OH CAS 167275-47-0 HPLC 99% α-Me Series

Product Description

Fmoc-α-Me-Pro-OH CAS 167275-47-0 HPLC 99% α-Me Series

Name: Fmoc-α-Me-Pro-OH

CAS NO: 167275-47-0

M.W: 351.4

Appearance: White Powder

HPLC: 99+  

Synonyms: (S)-N-Fmoc-α-Methyl-proline

Application

Double rigidity effect

Proline itself is a “helix breaker” and imposes strong conformational constraints.

Adding an α-methyl group further locks the backbone, making this residue extremely conformationally restricted.

Protease resistance

The extra α-methyl hinders enzymatic cleavage, improving peptide metabolic stability.

Conformational control

α-Me-Pro biases the peptide bond strongly towards cis or trans isomers, depending on the sequence context.

Useful for designing peptides with specific turns, loops, or β-hairpin structures.

Drug design applications

Enhances peptide oral bioavailability and stability in vivo.

Often employed in constrained peptide drugs or peptidomimetics to mimic protein–protein interaction hot spots.

Package

Transportation

Small package(1g, 25g, 1Kg, 25Kg) can be shipped by Express. (DHL, FedEx, EMS, etc.)
Large package(100kg and more than100Kg) can be transported by Air or Sea.

All transportation is in accordance with the customer's needs.

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