Fmoc-α-Me-Pro-OH CAS 167275-47-0 HPLC 99% α-Me Series

Proline itself is a “helix breaker" and imposes strong conformational constraints.

Adding an α-methyl group further locks the backbone, making this residue extremely conformationally restricted.

The extra α-methyl hinders enzymatic cleavage, improving peptide metabolic stability.

α-Me-Pro biases the peptide bond strongly towards cis or trans isomers, depending on the sequence context.

Useful for designing peptides with specific turns, loops, or β-hairpin structures.

Enhances peptide oral bioavailability and stability in vivo.

Often employed in constrained peptide drugs or peptidomimetics to mimic protein–protein interaction hot spots.