Fmoc-Dab(Cbz)-OH CAS 252049-08-4 HPLC 99% Fomc Derivatives

1. Peptide Synthesis

Fmoc-Dab(Cbz)-OH is an Fmoc-protected derivative of 2,4-diaminobutyric acid (Dab).

Commonly used as a building block in solid-phase peptide synthesis (SPPS).

The Fmoc group protects the α-amino group, while the Cbz group protects the side-chain amino group, allowing orthogonal deprotection and site-specific modification.

2. Modified Peptide Design

Used to introduce positive charge centers or hydrogen-bonding sites in peptides.

Useful in the synthesis of cationic antimicrobial peptides (AMPs), cell-penetrating peptides (CPPs), and peptidomimetics.

3. Branched or Cyclic Peptides

Enables side-chain functionalization for constructing branched, cyclic, or conjugated peptides (e.g., PEGylated or fluorescently labeled peptides).

The orthogonal protection pattern allows selective deprotection and coupling steps.

4. Drug Discovery & Research

Applied in the design of peptide-based drug candidates, particularly where secondary amine functionality or charge modulation is needed.

Sometimes used in linker design or crosslinking experiments in peptide libraries.