Fmoc-D-Pro-L-Pro-OH HPLC 98%+ Fmoc-AA Impurity Research

1️⃣ Solid-Phase Peptide Synthesis (SPPS)

• Used as a dipeptide building block in Fmoc-based solid-phase peptide synthesis

• Enables the direct incorporation of a D/L-configured Pro–Pro motif, reducing racemization risk and coupling inefficiencies associated with stepwise amino acid addition

• Commonly applied to:

  • Construction of proline-rich peptides

  • Improvement of synthetic efficiency and sequence fidelity

2️⃣ Conformational Restriction and β-Turn Induction

• Proline exhibits strong conformational constraints due to its cyclic structure

• The D-Pro–L-Pro motif is widely employed to:

  • Induce β-turn or β-hairpin structures

  • Stabilize defined secondary structures

• Plays a critical role in structural biology and structure–activity relationship (SAR) studies

3️⃣ Cyclic Peptide and Peptidomimetic Design

• Commonly used in:

  • Cyclic peptide synthesis

  • Conformational locking of peptide-based drug candidates

• Contributes to:

  • Enhanced metabolic stability

  • Improved binding selectivity toward biological targets

4️⃣ Protein–Protein Interaction (PPI) Inhibitor Research

• Proline-rich motifs are frequently found at protein–protein interaction interfaces

• The D-Pro–L-Pro unit can:

  • Mimic native turn structures

  • Serve as a structural element in the design of PPI-inhibitory peptides or peptidomimetics