Fmoc-L-Pro-D-Pro-OH HPLC 98%+ Fmoc-AA Impurity Research

1️⃣ Solid-Phase Peptide Synthesis (SPPS)

• Used as a dipeptide building block in Fmoc-based solid-phase peptide synthesis

• Enables direct incorporation of an L/D-configured Pro–Pro motif, minimizing racemization and coupling inefficiencies associated with stepwise amino acid assembly

• Particularly useful for:

  • Proline-rich peptide sequences

  • Improving synthetic efficiency and sequence accuracy

2️⃣ Conformational Control and Turn Modulation

• Proline imposes strong conformational rigidity due to its cyclic pyrrolidine ring

• The L-Pro–D-Pro motif is known to:

  • Promote specific turn geometries, often distinct from D-Pro–L-Pro

  • Modulate backbone dihedral angles and local folding patterns

• Widely applied in peptide folding studies and conformation–function investigations

3️⃣ Cyclic Peptide and Peptidomimetic Design

• Employed in:

  • Cyclic peptide synthesis

  • Conformationally constrained peptidomimetics

• Benefits include:

  • Improved proteolytic resistance

  • Enhanced structural definition and target selectivity

4️⃣ Protein–Protein Interaction (PPI) Modulation

• Proline-rich motifs frequently participate in protein–protein interaction interfaces

• The L-Pro–D-Pro dipeptide can:

  • Mimic non-canonical turn structures

  • Serve as a scaffold element in the design of PPI modulators or inhibitory peptides

5️⃣ Proline-Rich and Collagen-Related Peptide Models

• Used as a model unit to study:

  • The influence of proline stereochemistry on peptide folding

  • Structural differences between L/D vs D/L Pro-Pro motifs

• Valuable in collagen-mimetic and proline-rich peptide research