Fmoc-β-Ala-Tyr(tBu)-OH HPLC 98%+ HNMR In Accordance with Structure Fmoc-AA Impurity

Fmoc-β-Ala-Tyr(tBu)-OH HPLC 98%+ HNMR In Accordance with Structure Fmoc-AA Impurity

High-purity Fmoc-β-Ala-Tyr(tBu)-OH for Impurity Research and pharmaceutical development.

Key Applications

Solid-Phase Peptide Synthesis (SPPS)

• Used as a dipeptide building block in Fmoc-based solid-phase peptide synthesis

• Allows direct incorporation of a β-alanine–tyrosine motif, reducing stepwise coupling reactions and improving overall synthetic efficiency

• The tert-butyl protection on tyrosine prevents phenolic side-chain reactions during peptide assembly

2️⃣ Spacer and Flexibility Modulation

• β-Alanine (β-Ala) acts as a non-proteinogenic spacer with increased backbone flexibility

• Introduction of β-Ala can:

  • Extend peptide length without adding steric bulk

  • Adjust the distance and orientation between functional residues

• Commonly used in linker design and peptide optimization studies

3️⃣ Conformational and Functional Tuning

• The combination of flexible β-Ala and aromatic Tyr residue enables:

  • Fine-tuning of local peptide conformation

  • Modulation of hydrophobic and π–π interactions

• Useful in structure–activity relationship (SAR) investigations

4️⃣ Peptide Drug and Probe Development

• Frequently employed in:

  • Peptide therapeutics

  • Receptor-binding peptides

  • Peptide-based probes and conjugates

• The Tyr residue may serve as:

  • A recognition or binding site

  • A handle for further functionalization after deprotection

5️⃣ Bioconjugation and Functional Peptide Design

• After removal of the tBu group, the phenolic hydroxyl of tyrosine can be used for:

  • Labeling (fluorescent tags, radiolabels)

  • Attachment of pharmacophores or linkers

• β-Ala improves accessibility of the functional Tyr side chain

Packaging Options

Transportation

Small packages (1g, 25g, 1Kg, 25Kg) can be shipped by Express (DHL, FedEx, EMS, etc.). Large packages (100kg and more than 100Kg) can be transported by Air or Sea. All transportation is arranged according to customer requirements.

Company Profile