Fmoc-β-Ala-Trp(Boc)-OH HPLC 98%+ HNMR Fmoc-Trp(Boc)-OH Impurity

Fmoc-β-Ala-Trp(Boc)-OH HPLC 98%+ HNMR Fmoc-Trp(Boc)-OH Impurity

High-purity Fmoc-β-Ala-Trp(Boc)-OH for Impurity Research and pharmaceutical development.

Key Applications

Fmoc-β-Ala-Trp(Boc)-OH – Applications and Significance

1️⃣ Solid-Phase Peptide Synthesis (SPPS)

• Used as a dipeptide building block in Fmoc-based solid-phase peptide synthesis

• Enables direct incorporation of a β-alanine–tryptophan motif, reducing stepwise coupling reactions and improving synthetic efficiency

• The Boc protection on the indole nitrogen of tryptophan prevents side reactions during peptide assembly

2️⃣ Spacer and Distance Control

• β-Alanine (β-Ala) serves as a non-proteinogenic spacer with enhanced backbone flexibility

• Incorporation of β-Ala allows:

  • Fine adjustment of inter-residue spacing

  • Improved accessibility of bulky aromatic residues such as tryptophan

• Frequently applied in linker design and peptide optimization

3️⃣ Conformational and Interaction Modulation

• The combination of flexible β-Ala and aromatic Trp residue supports:

  • Modulation of local peptide conformation

  • Enhancement of hydrophobic interactions and π–π stacking

• Valuable in structure–activity relationship (SAR) studies

4️⃣ Peptide Drug and Probe Development

• Commonly used in:

  • Peptide therapeutics

  • Receptor-binding and signaling peptides

  • Fluorescent or spectroscopic probes (Trp intrinsic fluorescence)

• The Trp residue often plays a key role in binding affinity and specificity

5️⃣ Functional and Bioconjugation Applications

• After Boc deprotection, the indole NH of tryptophan can participate in:

  • Hydrogen bonding interactions

  • Further chemical modification if required

• β-Ala improves the presentation and flexibility of the Trp side chain

Packaging Options

Transportation

Small packages (1g, 25g, 1Kg, 25Kg) can be shipped by Express (DHL, FedEx, EMS, etc.). Large packages (100kg and more than 100Kg) can be transported by Air or Sea. All transportation is arranged according to customer requirements.

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