Fmoc-Ile-Aib-OH Raw Materials Boc-Ile-OH CAS NO. 13139-16-7

Peptide Synthesis

Boc-L-Ile-OH is a widely used N-Boc protected amino acid in liquid-phase peptide synthesis (LPPS). It serves as a key building block for the preparation of dipeptides, oligopeptides, and peptide active pharmaceutical ingredient (API) intermediates. After peptide coupling, the Boc protecting group can be readily removed under acidic conditions, enabling efficient elongation of peptide chains.

Peptide API Manufacturing

Boc-L-Ile-OH is commonly employed as an intermediate in the manufacture of therapeutic peptides, particularly for processes utilizing the Boc protection strategy. It is used in the synthesis of peptide fragments and advanced intermediates for peptide drug development and commercial production, contributing to high stereochemical purity and reliable process performance.

Drug Development

Boc-L-Ile-OH serves as a valuable chiral intermediate in pharmaceutical research and development. It is used for the synthesis of amino acid derivatives, peptide-based drug candidates, and other bioactive compounds. The Boc protecting group enhances synthetic selectivity, improves product purity, and facilitates downstream deprotection and functional group transformations.

Building Block for Peptide Intermediates

Boc-L-Ile-OH is an important precursor for the synthesis of a wide range of peptide intermediates, including Boc-Ile-Aib-OH, Boc-Ile-Gly-OH, Boc-Ile-Val-OH, and other Ile-containing peptide fragments. These intermediates are widely used in medicinal chemistry, peptide optimization, and commercial peptide manufacturing.