98+ White Powder Fmoc-L-Val-Cit-PAB-OH CAS NO.159858-22-7

Product Description

White Powder Fmoc-L-Val-Cit-PAB-OH  CAS NO.159858-22-7  Purity 98+

Name: Fmoc-L-Val-Cit-PAB-OH

CAS NO: 159858-22-7

M.W:601.69

Appearance: White Powder

Purity: 98+   

Synonyms: FMoc-Val-Cit-PAB;Fmoc-Val-Cit-PAB-OH;(9H-fluoren-9-yl)methyl((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate;L-Ornithinamide,N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-;(9H-fluoren-9-yl)methyl((S)-1-((())-1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate;(9H-fluoren-9-yl)methylN-[(1S)-1-{[(1S)-4-(carbamoylamino)-1-{[4-(hydroxymethyl)phenyl]carbamoyl}butyl]carbamoyl}-2-methylpropyl]carbamate;Fmoc-val-citrulline-para-aminobenzyl-OH;(9H-fluoren-9-yl)methyl((2S)-1-((1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate

Application

Peptide synthesis - Fmoc-L-Val-Cit-PAB-OH is primarily used as a protected amino acid in peptide synthesis, particularly in the construction of peptides with specific sequences and functions. Its Fmoc group can be removed under appropriate conditions to enable further elongation of the peptide chain.

Drug discovery - Due to its role as a cleavable ADC linker, Fmoc-L-Val-Cit-PAB-OH has found widespread application in the field of drug discovery. ADC drugs couple antibodies with cytotoxic agents using the linker to target specific cells. The linker's cleavage site can be recognized by specific enzymes within the cell, releasing the cytotoxic agent and exerting its therapeutic effect.

Biomedical research - Fmoc-L-Val-Cit-PAB-OH can also be used in biomedical research, for instance in the synthesis of peptide probes or enzyme inhibitors for studying biological processes such as cell signaling or disease mechanisms.

Package

Transportation

Small package(1g, 25g, 1Kg, 25Kg) can be shipped by Express. (DHL, FedEx, EMS, etc.)
Large package(100kg and more than100Kg) can be transported by Air or Sea.

All transportation is in accordance with the customer's needs.

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