Fmoc-N-Me-Ala-OH CAS 84000-07-7 Fmoc-N-methyl-L-alanine

Product Description

Fmoc-N-Me-Ala-OH CAS 84000-07-7 Fmoc-N-Methyl-L-Alanine

Name: Fmoc-N-Me-Ala-OH

CAS NO: 84000-07-7

M.W: 325.36

Appearance: White Powder

Purity: 98+   

Synonyms: Fmoc-N-Methyl-L-Alanine

Application

Peptide Synthesis:

The primary application of Fmoc-N-Me-Ala-OH is in solid-phase peptide synthesis (SPPS). The Fmoc group serves to protect the amino group of the amino acid during the synthesis process, preventing unwanted reactions until the peptide chain is fully assembled. After coupling, the Fmoc group can be removed with a base to expose the amine for the next step.
N-methylation of alanine (N-Me-Ala) is useful for studying peptide conformation and biological activity, as methylation can alter peptide folding, stability, and interactions with receptors or enzymes. The N-methyl group can help mimic certain types of peptide modifications, potentially enhancing lipophilicity or stability.

Studying Peptide Structure and Stability:

N-methylation of alanine is commonly used to introduce stability or conformational constraints into peptides. The methyl group sterically hinders amide bond rotation, which can stabilize specific secondary structures, such as α-helices or β-turns. This is important in the design of peptides that need to retain their structure in complex biological environments.
N-methylated amino acids, such as N-Me-Ala, can be incorporated into peptides to study how subtle changes in structure affect protein folding, interaction with other biomolecules, and overall biological activity.

Package

Transportation

Small package(1g, 25g, 1Kg, 25Kg) can be shipped by Express. (DHL, FedEx, EMS, etc.)
Large package(100kg and more than100Kg) can be transported by Air or Sea.

All transportation is in accordance with the customer's needs.

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