N-Me-L-Ala-Otbu.Hcl CAS 103614-40-0 (S)-tert-Butyl 2-(methylamino)propanoate hydrochloride

Product Description

N-Me-L-Ala-Otbu.Hcl CAS 103614-40-0 (S)-tert-Butyl 2-(methylamino)propanoate hydrochloride

Name: N-Me-L-Ala-Otbu.Hcl

CAS NO: 103614-40-0

M.W: 195.69

Appearance: White Powder

Purity: 98+   

Synonyms: (S)-tert-Butyl 2-(methylamino)propanoate hydrochloride

Application

Peptide Synthesis:

The N-Me-L-Ala-OtBu·HCl derivative is often used in solid-phase peptide synthesis (SPPS). The tert-butoxy group is used to protect the carboxyl group of alanine during peptide bond formation. This is crucial for preventing side reactions or undesired coupling at the carboxyl site while assembling a peptide chain.
The N-methyl group at the amine group in N-Me-L-Ala influences the peptide’s structure, stability, and biological activity. The N-methylation generally prevents the peptide from adopting flexible conformations by reducing the rotation around the peptide bond, which can help stabilize specific secondary structures like alpha-helices or beta-turns.

Enhancing Peptide Stability:

The N-methylation of alanine increases the peptide's resistance to enzymatic degradation, making peptides containing this derivative more stable in biological environments. This is particularly useful when designing peptides for therapeutic use, as proteolytic resistance can increase their half-life in vivo.
N-Me-L-Ala is also used to make peptides more lipophilic, which can aid in crossing biological membranes or improving bioavailability.

Package

Transportation

Small package(1g, 25g, 1Kg, 25Kg) can be shipped by Express. (DHL, FedEx, EMS, etc.)
Large package(100kg and more than100Kg) can be transported by Air or Sea.

All transportation is in accordance with the customer's needs.

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