Boc-N-Me-Val-OH CAS 45170-31-8 Boc-N-Methyl-L-Valine

Product Description

Boc-N-Me-Val-OH CAS 45170-31-8 Boc-N-Methyl-L-Valine

Name: Boc-N-Me-Val-OH

CAS NO: 45170-31-8

M.W: 231.29

Appearance: White Powder

Purity: 98+   

Synonyms: Boc-N-Methyl-L-Valine

Application

Peptide Synthesis:

Boc-N-Me-Val-OH is primarily used in solid-phase peptide synthesis (SPPS). The Boc group protects the amine group on valine during the peptide chain elongation, preventing side reactions or unwanted coupling. After each step of peptide bond formation, the Boc group can be removed using a mild acid (typically trifluoroacetic acid, TFA), leaving the amine group available for the next step in synthesis.

The N-methyl group stabilizes the peptide by reducing flexibility in the peptide backbone. This can enhance peptide stability and bioactivity, particularly when N-methylvaline is incorporated into biologically active peptides.

Enhancing Stability and Bioactivity:

N-methylation in amino acids like N-Me-Val can improve the protease resistance of the peptide, making it less susceptible to enzymatic degradation in biological systems. This is beneficial for designing peptides with longer half-lives and enhanced stability.
The addition of N-methyl groups can also increase the hydrophobicity of peptides, potentially improving cellular uptake or membrane penetration.

Package

Transportation

Small package(1g, 25g, 1Kg, 25Kg) can be shipped by Express. (DHL, FedEx, EMS, etc.)
Large package(100kg and more than100Kg) can be transported by Air or Sea.

All transportation is in accordance with the customer's needs.

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