Cbz-N-Me-Val-OH CAS 42417-65-2 Cbz-N-methyl-L-valine

Product Description

Cbz-N-Me-Val-OH CAS 42417-65-2 Cbz-N-methyl-L-valine

Name: Cbz-N-methyl-L-valine

CAS NO: 42417-65-2

M.W: 265.3

Appearance: White Powder

Purity: 98+   

Synonyms: N-((Benzyloxy)carbonyl)-N-methyl-L-valine

Application

Peptide Synthesis:

Cbz-N-Me-Val-OH is commonly used in solid-phase peptide synthesis (SPPS). The Cbz group is used to protect the amine of valine during the elongation process. The N-methyl group on the side chain helps stabilize the peptide by limiting flexibility and increasing protease resistance.
The Cbz group can be removed after synthesis using hydrogenation or acidic conditions, allowing the amine to be exposed for the next coupling step.

Increased Stability and Bioactivity:

N-methylated amino acids such as N-Me-Val are often used to make peptides more resistant to proteolytic enzymes, making them more stable in biological systems. This is particularly useful in designing therapeutic peptides that require longer circulation times in the body.
The N-methylation increases hydrophobicity and can help peptides interact better with lipophilic receptors or cell membranes, improving cellular uptake or biological activity.

Package

Transportation

Small package(1g, 25g, 1Kg, 25Kg) can be shipped by Express. (DHL, FedEx, EMS, etc.)
Large package(100kg and more than100Kg) can be transported by Air or Sea.

All transportation is in accordance with the customer's needs.

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