N-Me-Val-OH CAS 2480-23-1 N-Methyl-L-valine

Product Description

N-Me-Val-OH CAS 2480-23-1 N-Methyl-L-valine

Name: N-Me-Val-OH

CAS NO: 2480-23-1

M.W: 131.17

Appearance: White Powder

Purity: 98+   

Synonyms: N-Methyl-L-valine

Application

Peptide Synthesis:

N-Me-Val-OH is useful in solid-phase peptide synthesis (SPPS), where it can be incorporated into peptides to study the effects of methylation on their structure and function. The N-methylation can increase peptide stability by reducing protease susceptibility and improving the lipophilicity of the peptide.
Methylation at the amine group in the side chain of valine can also restrict peptide flexibility, making it useful for designing peptides with specific secondary structures such as α-helices or β-turns.

Stability Enhancement:

N-methylation is often used to make peptides more resistant to enzymatic degradation, especially from proteases that cleave peptide bonds. This makes N-Me-Val-OH valuable in the design of therapeutic peptides that need to be stable in the bloodstream or other biological environments.
Methylation can also increase the hydrophobicity of the peptide, which can enhance its ability to penetrate lipid membranes or interact with lipophilic receptors.

Studying Protein Structure and Folding:

N-Me-Val can be used to study peptide conformation and protein folding. By introducing N-methylvaline into peptides, researchers can examine how methyl groups influence conformational rigidity and the ability of peptides to adopt certain structures, such as α-helices or other biologically relevant conformations.
Methylation of valine can also alter the stereoelectronic properties of the peptide, which could influence how the peptide interacts with biological targets like enzymes or receptors.

Package

Transportation

Small package(1g, 25g, 1Kg, 25Kg) can be shipped by Express. (DHL, FedEx, EMS, etc.)
Large package(100kg and more than100Kg) can be transported by Air or Sea.

All transportation is in accordance with the customer's needs.

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