Fmoc-N-Me-Leu-OH CAS 103478-62-2 Fmoc-N-Methyl-L-Leucine

Product Description

Fmoc-N-Me-Leu-OH CAS 103478-62-2 Fmoc-N-Methyl-L-Leucine

Name: Fmoc-N-Me-L-Leu-OH

CAS NO: 103478-62-2

M.W: 367.44

Appearance: White Powder

Purity: 98+   

Synonyms: N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-leucine

Application

Increased Hydrophobicity and Membrane Penetration:

N-methylation generally increases the hydrophobicity of the peptide, which enhances its ability to interact with hydrophobic environments, such as cell membranes or lipid bilayers. This property is often leveraged when designing peptides or peptide-based drugs that need to penetrate cellular membranes or interact with membrane-bound receptors.

Peptide Conformation and Bioactivity:

The N-methylation restricts the rotation around the amine bond in the leucine side chain, potentially helping the peptide adopt a more rigid structure. This can be beneficial for receptor binding, selectivity, and bioactivity.
N-methylated peptides often show improved binding affinity to their targets (e.g., receptors, enzymes) due to the stabilization of specific secondary structures (such as α-helices or β-turns).

Package

Transportation

Small package(1g, 25g, 1Kg, 25Kg) can be shipped by Express. (DHL, FedEx, EMS, etc.)
Large package(100kg and more than100Kg) can be transported by Air or Sea.

All transportation is in accordance with the customer's needs.

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