Fmoc-N-Me-Ser(tBu)-OH CAS 197632-77-2 Fmoc-N-methyl-O-tert-butyl-L-serine

Product Description

Fmoc-N-Me-Ser(tBu)-OH CAS 197632-77-2 Fmoc-N-methyl-O-tert-butyl-L-serine

Name: Fmoc-N-Me-Ser(tBu)-OH

CAS NO: 197632-77-2

M.W: 397.46

Appearance: White Powder

Purity: 98+   

Synonyms: Fmoc-N-methyl-O-tert-butyl-L-serine; Fmoc-MeSer(tBu)-OH

Application

Increased Stability and Protease Resistance:

The N-methylation of the serine side chain improves the rigidity and stability of peptides, helping to resist enzymatic cleavage by proteases. N-methylserine is more resistant to enzymatic hydrolysis compared to unmodified serine.
This makes Fmoc-N-Me-Ser(tBu)-OH useful in the synthesis of peptides that are designed to be more stable in biological systems or those that need to withstand protease digestion in therapeutic applications.

Control Over Peptide Conformation:

N-methylation can help stabilize the peptide’s secondary structure by reducing the flexibility of the peptide backbone. This can be important when designing peptides with specific conformations (e.g., α-helical structures or β-turns) required for receptor binding or enzyme inhibition.
The modification can be used to induce or stabilize a specific tertiary structure, which can be crucial for target specificity in drug development.

Hydrophilicity and Membrane Interaction:

The N-methyl group increases the hydrophobicity of the peptide, potentially improving its ability to interact with lipophilic receptors or penetrate lipid membranes.
The tert-butyl group adds a steric hindrance that may alter how the peptide interacts with hydrophobic environments or membrane-bound targets.

Package

Transportation

Small package(1g, 25g, 1Kg, 25Kg) can be shipped by Express. (DHL, FedEx, EMS, etc.)
Large package(100kg and more than100Kg) can be transported by Air or Sea.

All transportation is in accordance with the customer's needs.

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