Tri-peptide Gly-Gly-Phe 6234-26-0 White Powder HPLC 99+

Product Description

Tri-peptide Gly-Gly-Phe 6234-26-0 White Powder HPLC 99+

Name: Gly-Gly-Phe

CAS NO: 6234-26-0

M.W: C13H17N3O4

Appearance: White Powder

Purity: 98+

Synonyms: Gly-Gly-Phe

Application

Drug Delivery & Targeted Release

 Enzyme-Responsive Drug Delivery Systems

Application: Gly-Gly-Phe is employed as an enzyme-sensitive linker in drug delivery systems. It is often used in antibody-drug conjugates (ADCs) or nanoparticle-based delivery systems, where the linker is cleaved by specific enzymes present in the tumor microenvironment or other targeted areas.

Mechanism: When the drug system reaches a specific site, such as a tumor, enzymes (like cathepsins) cleave the Gly-Gly-Phe linker, releasing the active drug at the target site. This reduces the toxicity of the drug to healthy tissues and enhances the therapeutic effect.

Real-World Example: Chemotherapeutic drugs are often designed with such enzyme-sensitive linkers to increase their specificity for tumor cells.

Prodrug Design

Application: Gly-Gly-Phe can be incorporated into prodrug designs, where the peptide acts as a precursor molecule that is inactive until cleaved by specific enzymes in the body. This activation process helps deliver the drug selectively and safely to targeted tissues.

Example: Some antibiotics or antiviral drugs are designed with peptide linkers, like Gly-Gly-Phe, to enhance their oral bioavailability and activation upon entering the bloodstream.

Package

Transportation

Small package(1g, 25g, 1Kg, 25Kg) can be shipped by Express. (DHL, FedEx, EMS, etc.)
Large package(100kg and more than100Kg) can be transported by Air or Sea.

All transportation is in accordance with the customer's needs.

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