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Product Name: | Fmoc-Gly-Gly-Phe-OH | CAS No: | 160036-44-2 |
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M.W: | 501.53 | Appearance: | White Powder |
Purity: | 99+ | Storage: | Room Temperature |
Product Description
ADC Raw materials Fmoc-Gly-Gly-Phe-OH CAS NO. 160036-44-2 HPLC 99+
Name: Fmoc-Gly-Gly-Phe-OH
CAS NO: 160036-44-2
M.W: 501.53
Appearance: White Powder
Purity: 98+
Synonyms: Fmoc-Gly-Gly-Phe-OH
Application
1. Cleavable Linker Design
Fmoc-Gly-Gly-Phe-OH contains a Gly-Gly-Phe (GGF) tripeptide sequence that can serve as a protease-sensitive linker in ADCs.
This type of sequence is recognized and cleaved by lysosomal enzymes such as Cathepsin B, which are highly expressed in tumor cells.
Upon internalization of the ADC by the target cancer cell, the GGF linker is cleaved, triggering the release of the cytotoxic payload.
2. Enhanced Tumor Selectivity and Drug Release
The use of enzyme-sensitive linkers like GGF ensures that the drug is released specifically within the tumor environment, limiting systemic toxicity.
It contributes to precise and controlled intracellular release of the active drug (e.g., MMAE, DM1).
Package
Transportation
Small package(1g, 25g, 1Kg, 25Kg) can be shipped by Express. (DHL, FedEx, EMS, etc.)
Large package(100kg and more than100Kg) can be transported by Air or Sea.
All transportation is in accordance with the customer's needs.
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