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H-N-Me-Leu-Obzl.Tos CAS 42807-66-9 HPLC 99+ AADs
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Detailed Product Description
| Product Name: | H-N-Me-Leu-Obzl.Tos | CAS No: | 42807-66-9 |
|---|---|---|---|
| M.W: | 407.52 | Appearance: | White Powder |
| HPLC: | 99% | Storage: | Room Temp |
| Highlight: | H-N-Me-Leu-Obzl.Tos amino acid derivative,HPLC 99+ AADs with warranty,CAS 42807-66-9 amino acid |
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H-N-Me-Leu-Obzl.Tos CAS 42807-66-9 HPLC 99+ AADs
High-purity N-methyl-L-leucine benzyl ester tosylate for advanced peptide synthesis and pharmaceutical development.
| Name | H-N-Me-Leu-Obzl.Tos |
|---|---|
| CAS NO | 42807-66-9 |
| Molecular Weight | 407.52 |
| Appearance | White Powder |
| HPLC Purity | 99+% |
| Synonyms | N-ALPHA-METHYL-L-LEUCINE BENZYL ESTER P-TOSYLATE |
Key Applications
Incorporation of N-methyl Amino-Acid Residues
N-Me-Leu is commonly introduced into peptide backbones to achieve:
- Improved metabolic stability
- Reduced susceptibility to proteolytic degradation
- Conformational restriction and better structural control
- Enhanced membrane permeability and oral bioavailability
It is widely used in:
- Cyclic peptides
- Macrocyclic drug scaffolds
- Cell-penetrating peptides
- Backbone-modified peptides
Intermediate for Pharmaceutical Peptide Development
N-Me-Leu is a key structural element in many bioactive peptides, including:
- GPCR ligands
- Protease inhibitors
- Antimicrobial and anticancer peptides
- Immunomodulatory peptides
The presence of an N-methyl residue significantly improves the drug-like properties of peptide candidates.
Backbone and Side-Chain Engineering
Because N-methylation modifies the hydrogen-bonding pattern and backbone torsion angles, this reagent is frequently used for:
- Protein-protein interaction modulation
- Enhancing peptide rigidity and stability
- Designing peptides with improved selectivity and binding affinity
Fragment Condensation and SPPS Applications
With a free N-terminus (H-N-) and a benzyl-protected C-terminus (OBzl), it is suitable for:
- Liquid-phase fragment condensation
- Incorporation into difficult or aggregation-prone sequences
- Selective deprotection of OBzl under hydrogenation conditions (Pd/C + H₂)
Its tosylate salt form improves handling, stability, and storage.
Useful in "Difficult Sequence" Peptide Assembly
Introducing N-Me-Leu helps to:
- Disrupt β-sheet formation
- Reduce aggregation during chain elongation
- Improve resin swelling and coupling efficiency
It is particularly valuable for hydrophobic peptides and amyloid-prone sequences.
Packaging Options
Transportation
Small packages (1g, 25g, 1Kg, 25Kg) can be shipped by Express (DHL, FedEx, EMS, etc.). Large packages (100kg and more than 100Kg) can be transported by Air or Sea. All transportation is arranged according to customer requirements.
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